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Watch Jaguars vs 49ers Live Stream Week 12 NFL. Jacksonville’s last trip to the West Coast more than a month ago proved to be a turning point in its season. A more confident team since then, the Jaguars look for a fourth straight victory when they again head west to face the San Francisco 49ers on Sunday. Even before they took the field, the Jaguars (6-4) should have known their trip to Seattle on Oct. 11 wouldn’t be a good one. Watch Jaguars vs 49ers Live Stream.